Anti-Biotic and Combinations


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Anti-Biotic and Combinations

MOXIFLOXACIN EYE DROPS IP 0.5% w/v. (Viscosity not less than 250 centipoise)

Each ml contains: Moxifloxacin Hydrochloride IP Equivalent to Moxifloxacin ..... 0.5% w/v, Sterile Aqueous Base ..... q.s.

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Moxifloxacin is a fourth-generation 8-methoxy fluoroquinolone antibacterial agent having a broad-spectrum activity with enhanced Gram-positive coverage, maintain Gram-negative activity and also active against a typical microorganisms, Mycobacterium and anaerobes. The bactericidal action of Moxifloxacin results from inhibition of enzymes DNA gyrase and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.
Moxifloxacin has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described below

Moxieye Gel is indicated for the treatment of bacterial conjunctivitis caused by susceptible
strains and post-operative prophylaxis from susceptible strains

Instill one drop in the affected eye 3 times a day for 7 days or as directed by the ophthalmologist. Moxieye Gel being a viscous liquid is retained on the ocular surface for a longer time, therefore the dosage may be determined by the ophthalmologist, after assessing the therapeutic response and condition of the patient.

In patients receiving systemically administered quinolones, including moxifloxacin, serious and occasionally fatal hypersensitivity (anaphylactic), reactions have been reported, some following the first dose. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema (including
laryngeal, pharyngeal or facial edema), airway obstruction, dyspnea, urticaria, and itching. If an allergic reaction to moxifloxacin occurs, discontinue use of the drug. Serious acute hypersensitivity reactions may require immediate emergency treatment. Oxygen and airway management should be administered as
clinically indicated.

The most frequently reported ocular side effects were conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage, and tearing. These events occurred in approximately 1-6% of patients. Nonocular adverse events reported at a rate of 1-4% were fever, increased cough, infection, otitis media, pharyngitis, rash, and rhinitis.

Moxieye Gel solution having visosity not less than 250 centipoise in a container of 5 ml.

Storage :
Store in cool & dry place. Protect from light. Use the solution within one month after opening the container. For external use only

Medicine :
Keep out of reach of children.
Use the solution within one month after opening the container.
For external use only.

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